charcot-marie-tooth disease：Charcot–Marie–Tooth disease

Neuromuscular disease

Medical condition

Charcot–Marie–Tooth diseaseOther namesCharcot–Marie–Tooth neuropathy, peroneal muscular atrophy, Dejerine-Sottas syndromeThe foot of a person with Charcot–Marie–Tooth disease: The lack of muscle, a high arch, and claw toes are signs of this genetic disease.PronunciationSpecialtyNeurology, podiatry, orthopedics, physical medicine and rehabilitationSymptomsFoot drop, hammertoe, peripheral muscle wasting of lower legs and lower arm/handsUsual onsetChildhood – early adulthoodDurationLifelongCausesFamily history (genetics)Risk factorsFamily history (genetics), high-arched feet, flat-arched feetDiagnostic methodGenetic testing, nerve conduction study or electromyogram (EMG)Differential diagnosisMuscular dystrophyTreatmentManagement to maintain functionPrognosisProgressiveFrequencyPrevalence: 1 in 2,500[1][2]

Charcot–Marie–Tooth disease (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized by ...