Advances in synthetic lethality for cancer therapy：Advances in synthetic lethality for cancer therapy
Advances in synthetic lethality for cancer therapy
Clinically,thetreatmentstrategybasedonsyntheticlethalityhasthreemajorbenefits:(1)asyntheticlethality-basedtreatmentstrategycouldbeutilizedagainstthemajorityofcancermutations,(2)syntheticlethalityallowssimpleidentificationo。其他文章還包含有：「Advancesinsyntheticlethalityforcancertherapy」、「Developmentofsyntheticlethalityincancer」、「NewHorizonsofSyntheticLethalityinCancer」、「Thepowerandt...
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Advances in synthetic lethality for cancer therapy
https://jhoonline.biomedcentra
It has been demonstrated that the synthetic lethal approach can be used to treat breast and ovarian cancer cells by inducing senescence with ...
Development of synthetic lethality in cancer
https://www.nature.com
Based on these clinical trials, the FDA first approved olaparib for the treatment of advanced-stage, BRCA1/2-mutant ovarian cancers in 2014.
New Horizons of Synthetic Lethality in Cancer
https://pubs.acs.org
This Perspective focuses on the most recent progress in synthetic lethal targets and their inhibitors, within and beyond the DNA damage response ...
The power and the promise of synthetic lethality for clinical ...
https://www.sciencedirect.com
Research progress of gene target based on synthetic lethality. SL has already demonstrated efficacy as a therapeutic strategy in targeting certain tumor types ...
The biological essence of synthetic lethality
https://onlinelibrary.wiley.co
Initially studied in yeast and Drosophila models, the concept of SL has significantly advanced targeted cancer therapies. Hartwell and ...
Unleashing the Power of Synthetic Lethality
https://www.mdpi.com
With advances in technology, the five most common cancer treatments to date include physiotherapy–surgical resection, radiotherapy, chemotherapy, targeted ...