Car signaling：Chimeric antigen receptor signaling
Chimeric antigen receptor signaling
由SELindner著作·2020·被引用131次—CARs,unliketheTCRstheymimic,consistofmoleculesinwhichtumorantigenrecognitionandintracellularactivationarecombined.Their ...。其他文章還包含有：「CARSignalingNetworksInteractivePathway」、「Tuningchargedensityofchimericantigenreceptor...」、「SignalingfromTcellreceptors(TCRs)andchimeric...」、「RecentadvancesonCAR」、「RewiredsignalingnetworkinTcellsexpressingth...
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CAR Signaling Networks Interactive Pathway
https://www.cellsignal.com
CARs are synthetic proteins with a modular design intended to engage the endogenous cell signaling cascades that elicit effector T-cell functions—including ...
Tuning charge density of chimeric antigen receptor ...
https://www.nature.com
Our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the ...
Signaling from T cell receptors (TCRs) and chimeric ...
https://www.ncbi.nlm.nih.gov
TCR and CAR signaling plays a critical role in determining the T cell state, including exhaustion and memory.
Recent advances on CAR
https://www.frontiersin.org
This review highlights ongoing research aimed at elucidating the role of CAR domains and T-cell signaling molecules involved in these processes.
Rewired signaling network in T cells expressing the ...
https://www.embopress.org
The chimeric antigen receptor (CAR) triggers a rewired signaling pathway to activate T cells as compared to the T cell receptor (TCR).
CAR and TCR form individual signaling synapses and do ...
https://www.frontiersin.org
Chimeric antigen receptors (CARs) can be remarkably powerful in redirecting a T cell response towards defined target cells (1) while utilizing the TCR/CD3 ...