CAR T cell therapy：CAR T Cells

Co-stimulatory signaling domains have been added to newer generations of CAR T cells to improve their ability to produce more T cells after infusion and survive longer in the circulation.

Credit: Brentjens R, et al. “Driving CAR T cells forward.” Nat Rev Clin Oncol. 2016 13, 370–383.

For decades, the foundations of cancer treatment have been surgery, chemotherapy, and radiation therapy. These continue to be critical mainstays of treatment, but new categories of treatment have recently helped transform the treatment picture for people with cancer.

The 2000s marked the emergence of targeted therapies like imatinib (Gleevec)[1] and trastuzumab (Herceptin)[2]—drugs that find and kill cancer cells by homing in on specific molecular changes seen primarily in those cells. Dozens of tar...