Carbamate hydrolysis：Organic Carbamates in Drug Design and Medicinal Chemistry
Organic Carbamates in Drug Design and Medicinal Chemistry
由AKGhosh著作·2015·被引用721次—Fasthydrolysisofcarbamate-bearingdrugsmayresultinweakorshortenedactivity.Onthecontrary,carbamate-basedprodrugsmustundergo ...。其他文章還包含有：「Basichydrolysisofcarbamatetoamineinaqueousethanol」、「Elimination–additionmechanismforthehydrolysis...」、「HydrolysisMechanismofCarbamateMethomylbyaNovel...」、「Hydrolysisofacarbamatetriggeredbycoordination...」、「...
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Basic hydrolysis of carbamate to amine in aqueous ethanol
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The aqueous potassium hydroxide/ethanol medium allows solubility of both base and organic carbamate, facilitating hydrolysis. By entirely ...
Elimination–addition mechanism for the hydrolysis ...
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The hydrolytic conversion of aryl carbamates to amines is base catalysed and evidence is presented that the process involves an 1cB elimination with the ...
Hydrolysis Mechanism of Carbamate Methomyl by a Novel ...
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The hydrolysis process involves two steps. In the first step, the H1 of Ser157 transfers to His284, while the O1 on the Ser157 attacks the ...
Hydrolysis of a carbamate triggered by coordination ...
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The reaction of the carbamate ligand H2L with chloride metal salts (M = Ni, Cu, Zn, Cd) leads to the coordination of the metal ions to the ligand, causing ...
Rates of hydrolysis of carbamate and carbonate esters in ...
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The data seemed to indicate two mechanisms for the hydrolysis of the carbamates: that initiated by an hydroxyl ion attachment on the central carbon atom followed by a carbamate ion intermediate, and that involving direct ionization of an amide hydrogen fo